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Gene modulation and severity of lung disease in cystic fibrosis
  1. A Pillai
  1. A Pillai, Specialty Trainee, Gloucestershire Royal Hospital, Gloucester, UK; anilkumarpillai{at}doctors.org.uk

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Progressive lung disease is an important cause of mortality and morbidity in patients with cystic fibrosis (CF). The severity and progression of lung disease, which has a poor correlation with CF transmembrane conductance regulator (CFTR) genotype, is thought to be modulated by secondary genetic factors known as CF modifiers. Mannose binding lectin 2 (MBL2) and transforming growth factor β1 (TGFβ1) genes are among …

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