Alpha-1-antitrypsin aerosolised augmentation abrogates neutrophil elastase-induced expression of cathepsin B and matrix metalloprotease 2 in vivo and in vitro

P Geraghty; M P Rogan; C M Greene; M L Brantly; S J O’Neill; C C Taggart; N G McElvaney

doi:10.1136/thx.2007.088559

Article info

Alpha-1-antitrypsin deficiency

Alpha-1-antitrypsin aerosolised augmentation abrogates neutrophil elastase-induced expression of cathepsin B and matrix metalloprotease 2 in vivo and in vitro

Authors

P Geraghty Pulmonary Research Division, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland PubMed articles Google scholar articles
M P Rogan Pulmonary Research Division, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland PubMed articles Google scholar articles
C M Greene Pulmonary Research Division, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland PubMed articles Google scholar articles
M L Brantly Department of Medicine, University of Florida, Gainesville, Florida, USA PubMed articles Google scholar articles
S J O’Neill Pulmonary Research Division, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland PubMed articles Google scholar articles
C C Taggart Pulmonary Research Division, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland PubMed articles Google scholar articles
N G McElvaney Pulmonary Research Division, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland PubMed articles Google scholar articles

Professor C C Taggart, School of Medicine and Dentistry, Queen’s University Belfast, Grosvenor Road, Belfast BT12 6BP, UK; c.taggart{at}qub.ac.uk

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Citation

Geraghty P, Rogan MP, Greene CM, et al

Alpha-1-antitrypsin aerosolised augmentation abrogates neutrophil elastase-induced expression of cathepsin B and matrix metalloprotease 2 in vivo and in vitro

Thorax 2008;63:621-626.

Publication history

Received August 7, 2007
Accepted January 9, 2008
First published February 4, 2008.

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September 01, 2022

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2008 BMJ Publishing Group Ltd and the British Thoracic Society

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