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Is bronchodilation required routinely before diagnostic sputum induction? Evidence from studies with tuberculosis
  1. A Dunleavy,
  2. R A M Breen,
  3. F Perrin,
  4. M C I Lipman
  1. 1
    Departments of Thoracic and HIV Medicine, The Royal Free Hospital, London, UK
  1. Dr A Dunleavy, Departments of Thoracic and HIV Medicine, The Royal Free Hospital, Pond St, London NW3 2QG, UK; annedunleavy{at}

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Sputum induction (SI) by inhalation of nebulised hypertonic saline is an efficient and non-invasive way of obtaining samples to assess airway inflammation and diagnose pulmonary infections such as tuberculosis (TB).1 2 Data published on the safety of SI are largely derived from subjects with obstructive lung disease. Yet on this basis a Working Group of the European Respiratory Society (ERS) recommended that all patients undergoing SI should receive pre-procedure bronchodilation with monitoring throughout by either serial forced expiratory volume in 1 s or peak expiratory flow rate (PEFR) measurements.3 Subjects with other respiratory conditions may not be at the …

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  • Funding: This study was supported by a grant from The Henry Smith Charity.

  • Competing interests: None.