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Pharmacogenetic basis for severe asthma exacerbations
  1. Shoaib Faruqi
  1. S Faruqi, Specialist Registrar, Respiratory Medicine, Castle Hill Hospital, Cottingham, Hull, UK; sfaruqi{at}

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Activation of CD23, a low affinity IgE receptor, results in downregulation of IgE-mediated immune responses. CD23 is encoded for by the Fc fragment of IgE low affinity II receptor (FCER2) gene. IgE levels may increase in children with asthma treated with inhaled corticosteroids, and this may be explained by a decrease in FCER2 expression by corticosteroids. Also, elevated IgE levels are …

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