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HIF1α in hypoxia
  1. Kris McLaughlin
  1. K McLaughlin, Princess Alexandra Hospital, Brisbane, Queensland, Australia; krismcl{at}doctors.org.uk

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Conjugation of small ubiquitin-related modifier proteins (SUMO) to form larger substrates has been implicated in the regulation of multiple cellular processes in mammals including transcription, cell signalling and cancer progression. This conjugation is a dynamic process that can be reversed by a family of Sentrin/SUMO-specific proteases (SENPs).

This study investigated the physiological consequences of SUMOylation and deSUMOylation …

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