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  1. Y Qiu,
  2. P K Jeffery
  1. Lung Pathology, Department of Gene Therapy, Imperial College London, Royal Brompton Hospital, London, UK
  1. Dr P K Jeffery, Lung Pathology, Department of Gene Therapy, Imperial College London, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK; p.jeffery{at}imperial.ac.uk

https://doi.org/10.1136/thx.2007.090563

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    We thank Monteseirín and Vega for their comments concerning the specificity of the clone EG2 (Pharmacia & UpJohn Diagnostics AB, Uppsala, Sweden), mouse anti-human eosinophil cationic protein (ECP) monoclonal antibody used by us (Thorax 2007;62:475–82). We read with interest their results of isolated cells,1 which lead the authors to suggest caution in our interpretation of paraffin wax embedded bronchial biopsies from patients experiencing severe exacerbations of asthma. We respond respectfully and as follows.

    Firstly, in our experience and those of the originator (Per Venge; recent personal communication), the cells invariably stained with EG2 have the characteristic morphology of eosinophils (ie, bi-lobed granular cells) whereas …

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