Article Text

Download PDFPDF

Paraneoplastic neurological syndrome and polyglandular autoimmune syndrome type 2 in a case of small cell lung cancer
  1. S Watanabe1,
  2. J Tanaka1,
  3. T Ohta1,
  4. H Yoshizawa2,
  5. F Gejyo1
  1. 1
    Department of Medicine (II), Niigata University Medical and Dental Hospital, Niigata-city, Niigata, Japan
  2. 2
    Bioscience Medical Research Centre, Niigata University Medical and Dental Hospital, Niigata-city, Niigata, Japan
  1. Dr J Tanaka, Department of Medicine (II), Niigata University Medical and Dental Hospital, 1-754 Asahimachi-dori, Chuo-ku, Niigata-city, Niigata 951-8520, Japan; juntatnk{at}med.niigata-u.ac.jp

Abstract

We report a female patient with small cell lung cancer (SCLC) and clinical findings consistent with polyglandular autoimmune syndrome type 2 (PGA2) and paraneoplastic neurological syndrome (PNS). To the best of our knowledge, this is the first reported case of SCLC associated with PGA2 and PNS. All of the autoantibodies detected before anticancer treatment decreased below the upper normal limits after serial treatment, and the patient’s clinical symptoms also improved. Cross reactivity of autoantibodies may have contributed to the complicated clinical picture of this patient.

View Full Text

Statistics from Altmetric.com

Footnotes

  • Competing interests: None declared.

  • Ethics approval: Ethics approval was obtained.

  • Patient consent: Obtained from patient's next of kin.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.