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Alpha-1-antitrypsin deficiency and increased lung cancer risk
  1. S K Chhetri
  1. Dr S K Chhetri, ST2 Medicine, Salford Royal NHS Foundation Trust, Salford M6 8HD, UK; chhetrisk{at}

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Lung cancer development is a multifaceted process involving environmental and genetic factors, but their intricate interaction and extent of predisposition remains ill-defined. This study investigated the role of alpha1-antitrypsin deficiency (α1ATD), chronic obstructive pulmonary disease (COPD) and tobacco smoke exposure in lung cancer development in 1856 patients with lung cancer. The two …

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