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Predicting development and progression of COPD
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Albers and colleagues1 recently concluded that “Lung function below the normal range and early respiratory signs predict the development and progression of COPD”. We have some concerns about the data. Table 2 in their article lists 151 subjects without baseline abnormalities. In 5 years, forced expiratory volume in 1 s (FEV1) fell by 200 ml and FEV1%/vital capacity (VC) by 5.2%, remarkably large declines for such subjects. We computed predicted values at ages 43 and 48 years according to 28 authors …
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