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Predicting development and progression of COPD
  1. P H Quanjer1,
  2. I Steenbruggen2,
  3. G Ruppel3,
  4. M P Swanney4
  1. 1
    Erasmus University, Rotterdam, The Netherlands
  2. 2
    Isala Klinieken, Zwolle, The Netherlands
  3. 3
    St Louis University Hospital, St Louis, Missouri, USA
  4. 4
    Respiratory Physiology Laboratory, Christchurch Hospital, New Zealand
  1. Dr P H Quanjer, Erasmus University, Rotterdam, The Netherlands; pquanjer{at}

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Albers and colleagues1 recently concluded that “Lung function below the normal range and early respiratory signs predict the development and progression of COPD”. We have some concerns about the data. Table 2 in their article lists 151 subjects without baseline abnormalities. In 5 years, forced expiratory volume in 1 s (FEV1) fell by 200 ml and FEV1%/vital capacity (VC) by 5.2%, remarkably large declines for such subjects. We computed predicted values at ages 43 and 48 years according to 28 authors …

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    M Albers T Schermer Y Heijdra J Molema R Akkermans C van Weel