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Mechanism of secondary bacterial infection following viral pulmonary infection (the viral-bacterial synergy)
  1. Bhagi Jayaraman
  1. Dr B Jayaraman, Specialist Registrar, South East Thames Deanery, London, UK; bhagi.jayaraman{at}

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This paper examines the mechanism causing secondary bacterial infection which often occurs after pulmonary viral infection. C57BL/6 mice were infected intranasally with influenza virus strain A/PR8/34(H1N1). By day 12 there was immune-mediated viral clearance; however, the mice showed a high susceptibility to pneumococcal infection during this recovery stage.

Normal initial bacterial clearance requires innate …

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