Background: There are many reference equations for the measurement of single breath carbon monoxide diffusing capacity of the lung (Tlco). However, the testing methodologies vary and there are no well documented studies that have developed reference equations for Tlco and alveolar volume (Va) in middle aged and older populations.
Aims: (1) Develop reference equations for Tlco in a middle aged population using the current American Thoracic Society/European Respiratory Society (ATS/ERS) guidelines; (2) compare the equations with those commonly used in laboratories around the world.
Methods: Healthy subjects (498 male and 474 female) aged 45–71 years were recruited as part of a larger epidemiological study. All participants completed a respiratory questionnaire and had spirometry and single breath Tlco (corrected for haemoglobin) measurements following ATS/ERS guidelines.
Results: Mean age was 58 years for males and 57 years for females. For males, factors that predicted Tlco were: height, age, age×height interaction and being an ex-smoker. For females, factors that predicted Tlco were: height, age, weight and an age×height interaction.
Conclusion: We have described new prediction equations for Tlco in a middle aged population that require validation in other populations.
Statistics from Altmetric.com
Funding: National Health and Medical Research Council grant.
Competing interests: None.
Ethics approval: The study was approved by the ethics committee at The Alfred, Melbourne, Australia.
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.