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Inhibition of NKCC1 may be beneficial in sepsis
  1. B Jayaraman
  1. B Jayaraman, Respiratory SpR, Royal Bournemouth Hospital, Bournemouth, UK; Bhagi.jayaraman{at}

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Mortality related to bacteraemic pneumonia remains high, and previous studies have shown that the Na+–K+–Cl cotransporter (NKCC1) may have an important role in causing acute lung injury secondary to compromise of the alveolar-capillary barrier. Under normal physiological conditions, NKCC1 plays a central role in salt transport and volume …

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