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Ventilation heterogeneity is a major determinant of airway hyperresponsiveness in asthma, independent of airway inflammation
  1. Sue R Downie1,
  2. Cheryl M Salome1,
  3. Sylvia Verbanck2,
  4. Bruce Thompson3,
  5. Norbert Berend1,4,
  6. Gregory G King1,4
  1. 1Woolcock Institute of Medical Research, Camperdown, Sydney, Australia
  2. 2Respiratory Division, Academic Hospital, Vrije Universiteit Brussels, 1090 Brussels, Belgium
  3. 3Department of Allergy, Immunology, and Respiratory Medicine, The Alfred Hospital and Monash University, Melbourne, Australia
  4. 4Department of Respiratory Medicine, Royal North Shore Hospital, Sydney, Australia
  1. Correspondence to:
    MsSue Downie
    Woolcock Institute of Medical Research, P O Box M77, Camperdown, NSW 2050, Australia; sued{at}woolcock.org.au

Footnotes

  • Published Online First 20 February 2007

  • This project was funded by the Cooperative Research Centre for Asthma.

  • Competing interests: The authors have the following potential conflicts of interest to declare: Cheryl M Salome states that her research group has received support from Boehringer Ingelheim, GlaxoSmithKline and AstraZeneca but these do not pose any conflict of interest for this paper. Norbert Berend serves on advisory boards for GlaxoSmithKline, Boehringer Ingelheim and AstraZeneca, and The Woolcock Institute of Medical Research of which he is the Director receives research grants from GlaxoSmithKline. Gregory King has received travel sponsorship from GlaxoSmithKline to attend the ATS ASM 2003 (approximately $A9000) and a GlaxoSmithKline meeting in 2003 (approximately $A10 000), travel sponsorship from AstraZeneca to attend ATS ASM 2004 (approximately $A10 000) and two AstraZeneca scientific meetings (approximate combined value $A20 000), an honorarium paid to his research institute from GlaxoSmithKline to speak at a sponsored conference in South East Asia ($A3000) in 2005, a travel grant from AstraZeneca to attend the ATS 2005 ($A6000) and a travel grant from GlaxoSmithKline to attend the ATS 2006 ($A5000). A proportion of Dr King’s research work is conducted at the Woolcock Institute of Medical Research which receives unrestricted grants from AstraZeneca, GlaxoSmithKline, Boehringer Ingelheim and Vita Medical for such work. The Woolcock Institute of Medical Research also has a consultancy agreement with Pfizer, Boehringer Ingelheim, AstraZeneca and GlaxoSmithKline for which Dr King provides consultancy services related to asthma and COPD. His research group receives a proportion of the grants and monies that arise from those companies as part of specific and general allocations of those funds for research purposes across all research groups of the Woolcock Institute of Medical Research. Dr King does not own any stocks, equity or patents that pose a conflict of interest.

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Footnotes

  • Published Online First 20 February 2007

  • This project was funded by the Cooperative Research Centre for Asthma.

  • Competing interests: The authors have the following potential conflicts of interest to declare: Cheryl M Salome states that her research group has received support from Boehringer Ingelheim, GlaxoSmithKline and AstraZeneca but these do not pose any conflict of interest for this paper. Norbert Berend serves on advisory boards for GlaxoSmithKline, Boehringer Ingelheim and AstraZeneca, and The Woolcock Institute of Medical Research of which he is the Director receives research grants from GlaxoSmithKline. Gregory King has received travel sponsorship from GlaxoSmithKline to attend the ATS ASM 2003 (approximately $A9000) and a GlaxoSmithKline meeting in 2003 (approximately $A10 000), travel sponsorship from AstraZeneca to attend ATS ASM 2004 (approximately $A10 000) and two AstraZeneca scientific meetings (approximate combined value $A20 000), an honorarium paid to his research institute from GlaxoSmithKline to speak at a sponsored conference in South East Asia ($A3000) in 2005, a travel grant from AstraZeneca to attend the ATS 2005 ($A6000) and a travel grant from GlaxoSmithKline to attend the ATS 2006 ($A5000). A proportion of Dr King’s research work is conducted at the Woolcock Institute of Medical Research which receives unrestricted grants from AstraZeneca, GlaxoSmithKline, Boehringer Ingelheim and Vita Medical for such work. The Woolcock Institute of Medical Research also has a consultancy agreement with Pfizer, Boehringer Ingelheim, AstraZeneca and GlaxoSmithKline for which Dr King provides consultancy services related to asthma and COPD. His research group receives a proportion of the grants and monies that arise from those companies as part of specific and general allocations of those funds for research purposes across all research groups of the Woolcock Institute of Medical Research. Dr King does not own any stocks, equity or patents that pose a conflict of interest.

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