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Pulmonary actinomycosis complicating infliximab therapy for Crohn’s disease
  1. R D Cohen,
  2. W R Bowie,
  3. R Enns,
  4. J Flint,
  5. J M Fitzgerald
  1. Departments of Medicine and Pathology, University of British Columbia, Vancouver, Canada
  1. Dr Richard Cohen, Room 11223, Gordon & Leslie Diamond Health Care Centre, 11th Floor, 2775 Laurel Street, Vancouver, BC V5Z 1M9, Canada; richardcohen{at}shaw.ca

Abstract

The use of anti-tumour necrosis factor (TNF) agents has expanded significantly over the past few years, particularly for rheumatological diseases and Crohn’s disease. A number of associated opportunistic infections have been observed as a result of suppression of T cell-mediated immunity, the most frequent being tuberculosis. We report the first case of pulmonary actinomycosis in a patient receiving regular infusions of infliximab, an anti-TNF agent, for Crohn’s disease.

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Footnotes

  • Competing interests: None.

  • Abbreviations:
    CD
    Crohn’s disease
    IL
    interleukin
    TNF
    tumour necrosis factor
    WBC
    white blood cells