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Are patients with coeliac disease at higher risk of tuberculosis?
On the basis of screening studies on healthy volunteers, coeliac disease is now recognised to affect 1% of the population.1 The current optimal serological testing for coeliac disease may be immunoglobin (Ig)A endomysial, IgA tissue transglutaminase or a combination of the two, with a positive predictive value in excess of 95% provided IgA deficiency is excluded. Patients with positive serology then require an endoscopic duodenal biopsy to confirm the presence of villous atrophy and thus a firm diagnosis of coeliac disease. A link between coeliac disease and tuberculosis was first suggested as far back as 1952, but there has been a paucity of data exploring this relationship other than case reports and case series.2 The initial focus was on gastrointestinal tuberculosis being one of the differential diagnoses for villous atrophy of the small bowel. However, in 1988 a report from Birmingham, UK, suggested that patients with coeliac disease seemed to have an increased …