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Multidrug resistance emerging in North London outbreak
  1. H Maguire1,
  2. M Ruddy2,
  3. G Bothamley3,
  4. B Patel4,
  5. M Lipman5,
  6. F Drobniewski6,
  7. M Yates6,
  8. T Brown6
  1. 1Health Protection Agency (HPA), London, UK
  2. 2Health Protection Agency Mycobacterium Reference Unit (HPA MRU), London, UK
  3. 3Homerton Hospital, London, UK
  4. 4North Middlesex Hospital, London, UK
  5. 5Royal Free Hospital, London, UK
  6. 6Health Protection Agency Mycobacterium Reference Unit (HPA MRU), London, UK
  1. Correspondence to:
    Dr H Maguire
    Health Protection Agency, London WC2A 2JE, UK; helen.maguire{at}hpa.org.uk

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We write on behalf of the Outbreak Control Committee (OCC) investigating an outbreak of isoniazid monoresistant tuberculosis (TB) affecting over 260 cases (222 in London) to alert clinicians about recent transmission of a multidrug resistant (MDRTB) component with unusual characteristics.

A unique genetic fingerprint on Restriction Fragment Length Polymorphism (RFLP) typing1 at the Health Protection Agency Mycobacterium Reference Unit (HPA MRU) has …

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