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Statin treatment and reduced risk of pneumonia in patients with diabetes
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  1. E M W van de Garde1,2,
  2. E Hak3,
  3. P C Souverein1,
  4. A W Hoes3,
  5. J M M van den Bosch4,
  6. H G M Leufkens1
  1. 1Utrecht Institute for Pharmaceutical Sciences (UIPS), Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht, The Netherlands
  2. 2St Antonius Hospital, Department of Clinical Pharmacy, Nieuwegein, The Netherlands
  3. 3University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, Utrecht, The Netherlands
  4. 4St Antonius Hospital, Department of Pulmonary Diseases, Nieuwegein, The Netherlands
  1. Correspondence to:
    E M W van de Garde
    Utrecht Institute for Pharmaceutical Sciences (UIPS), Department of Pharmacoepidemiology and Pharmacotherapy, Sorbonnelaan 16, 3583 CA Utrecht, The Netherlands; e.m.w.vandegarde{at}pharm.uu.nl

Abstract

Background: Recent prognostic studies have shown that previous treatment with statins is associated with a better outcome in patients admitted to hospital with pneumonia. Because of an increased risk of pneumonia in patients with diabetes, we assessed the effects of statin use on the occurrence of pneumonia in adult diabetic patients.

Methods: All patients with a diagnosis of diabetes (types 1 and 2) enlisted in the UK General Practice Research Database between 1 June 1987 and 21 January 2001 were included. A case-control study was performed with cases defined as patients with a first recorded diagnosis of pneumonia. For each case up to four controls were matched by age, sex, practice, and index date. Patients were classified as current users when the index date was between the start and end date of statin treatment. Conditional multiple logistic regression analysis was used to estimate the strength of the association between statin treatment and the occurrence of pneumonia.

Results: Statins were used in 1.1% of 4719 cases and in 2.1% of 15 322 matched controls (crude odds ratio (OR) 0.51, 95% CI 0.37 to 0.68). After adjusting for potential confounders, treatment with statins was associated with a significant reduction in the risk of pneumonia (adjusted OR 0.49, 95% CI 0.35 to 0.69). The association was consistent among relevant subgroups (cardiovascular diseases, pulmonary diseases) and independent of the use of other prescription drugs.

Conclusions: The use of statins is associated with a considerable reduction in the risk of pneumonia in diabetic patients. In addition to lowering the risk of cardiovascular disease, statins may be useful in preventing respiratory infections.

  • statins
  • pneumonia
  • prevention
  • epidemiology

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Footnotes

  • Published Online First 29 June 2006

  • None of the authors is involved in any organisation or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript.

  • None of the authors has in the past five years accepted the following from an organisation that may in any way gain or lose financially from the results of the study: reimbursement for attending a symposium, a fee for speaking, a fee for organising education, funds for research, funds for a member of staff, fees for consulting. None of the authors has in the past five years been employed by an organisation that may in any way gain or lose financially from the results or conclusions of the study, or holds any stocks or shares in an organisation that may in any way gain or lose financially from the results or conclusions of the study.

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