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Anti-inflammatory gene therapy in the donor improves graft function after lung transplantation
  1. A Fisher
  1. Consultant Respiratory and Transplant Physician, Freeman Hospital, Newcastle upon Tyne, UK; A.J.Fisher@newcastle.ac.uk

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Ischaemia-reperfusion injury remains an important cause of primary graft failure and early mortality after lung transplantation. Interleukin (IL)-1, an early response and potent pro-inflammatory cytokine, has been implicated in the pathophysiology. In this paper the role of transfection of donor lungs with an adenoviral vector for soluble type …

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