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Absence of C/EBPα may cause bronchial smooth muscle proliferation in asthma
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Proliferation of bronchial smooth muscle (BSM) cells occurs in the airways of asthmatic patients. Glucocorticoids exert antiproliferative effects via CCAAT/enhancer binding protein α (C/EBPα), an antiproliferative transcription factor. This paper studies signalling pathways in BSM cell proliferation from 20 asthmatic and 26 non-asthmatic subjects (lung cancer/CF/emphysema).
A series of elegant …