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Hepatotoxicity from pyrazinamide based anti-tuberculous therapy: protective effect from isoniazid and HIV infection?
  1. A E Boyd
  1. Research Registrar, Homerton University Hospital NHS Trust, UK;

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In 1999 the American Thoracic Society (ATS), the Centers for Disease Control and Prevention (CDC), and the Infectious Diseases Society of America (IDSA) endorsed a 2 month daily regimen of rifampin and pyrazinamide (2RZ) for the treatment of latent tuberculosis (TB) infection. This recommendation followed a prospective randomised trial in HIV infected persons showing that 2RZ had similar efficacy and safety to a 12 month regimen of daily …

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