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DETECTION OF EARLY DISEASE IN CF
Lung disease in cystic fibrosis (CF) begins early in the natural history of the condition and, in early life, it is difficult to detect early abnormalities with spirometry. The impact of the disease at this stage is unknown. In this month’s Thorax Brennan and colleagues describe a study in children with CF under age 6 who took part in a clinical programme to detect infections. The low frequency forced oscillation technique (LFFOT) was used to measure lung function. LFFOT has been shown to be useful in young children and partitions lung function into airway and pulmonary components. Inflammatory and infective changes were present in bronchoalveolar lavage fluid in all children. Analysis showed that there was a significant relationship between LFFOT measures and markers of inflammation such as LTB4, IL-8, and neutrophil numbers. This study shows …
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