Article Text

Download PDFPDF

Tuberculosis in contacts need not indicate disease transmission
  1. U R Dahle1,
  2. S Nordtvedt2,
  3. B A Winje1,
  4. T Mannsaaker1,
  5. E Heldal1,
  6. P Sandven1,3,
  7. H M S Grewal4,
  8. D A Caugant1
  1. 1Division of Infectious Disease Control, Norwegian Institute of Public Health, P O Box 4404, Nydalen, N-0403 Oslo, Norway
  2. 2Department of Thoracic Medicine, Haukeland University Hospital, P O Box 1, N-5021 Bergen, Norway
  3. 3Institute of Microbiology, Rikshospitalet University Hospital, N-0027 Oslo, Norway
  4. 4Section of Microbiology and Immunology, The Gade Institute, University of Bergen and Haukeland University Hospital, N-5021 Bergen, Norway
  1. Correspondence to:
    Dr U R Dahle
    Division of Infectious Disease Control, Norwegian Institute of Public Health, P O Box 4404, Nydalen, N-0403 Oslo, Norway; ulf.dahlefhi.no

Abstract

Background: Traditional contact investigation is an important tool for controlling tuberculosis. It may also help to indicate drug susceptibility patterns when Mycobacterium tuberculosis cultures are not available. Such investigations often underestimate the degree of transmission found by genotyping, but overestimation may also occur. This report is the result of a routine successive DNA restriction fragment length polymorphism (RFLP) analysis of M tuberculosis isolated in Norway.

Method: Fifteen immigrants belonging to the same community were notified with tuberculosis during February to September 2003. The mycobacterial isolates were analysed by RFLP.

Results: All 15 patients had social contact with each other and 13 belonged to the same church community. A total of 14 cultures were positive for M tuberculosis. Among these isolates, six different genotypes were found. Five patients had not acquired the infection from the putative source.

Conclusions: Reactivation of tuberculosis may occur in contacts during the development of an outbreak. In such situations, traditional contact investigations may overestimate the rate of transmission found by genotyping of M tuberculosis. When cultures are unavailable and presumed drug susceptibility patterns are based on that of contacts, such overestimation may lead to incorrect treatment of a patient. Contact investigations must be combined with genotyping of M tuberculosis to conclude how tuberculosis is transmitted. This is especially important in persons with several risk factors for infection.

  • tuberculosis
  • transmission
View Full Text

Statistics from Altmetric.com

Footnotes

  • Competing interests: URD is a scientist working with genotyping of Mycobacterium tuberculosis.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.