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Decreased pulmonary lactoferrin activity facilitates Pseudomonas biofilm formation in CF
  1. S J Kelly
  1. Consultant Respiratory Physician, Wrexham Maelor Hospital, North East Wales NHS Trust, Wrexham, UK; stephen.kelly@new-tr.nhs.wales.uk

https://doi.org/10.1136/thx.2004.la0130

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    ▴ Rogan MP, Taggart CC, Greene CM, et al. Loss of microbiological activity and increased formation of biofilm due to decreased lactoferrin activity in patients with cystic fibrosis. J Infect Dis2004;190:1245–53
    OpenUrlAbstract/FREE Full Text

    Lactoferrin is an important antimicrobial protein in the airways. In this study lactoferrin activity and Pseudomonas biofilm formation were investigated in sputum and bronchoalveolar lavage (BAL) fluid from age and genotype matched cystic fibrosis (CF) patients with and without P aeruginosa colonisation …

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