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SV40 as a causative agent in mesothelioma: a new twist to the story
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  1. Y C G Lee
  1. Wellcome Advanced Fellow, University College London and Honorary Chest Physician, Osler Chest Unit, Oxford, UK; ycgarylee@hotmail.com

https://doi.org/10.1136/thx.2004.la0128

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    ▴ Lopez-Rios F, Illei PB, Rusch V, Ladanyi M. Evidence against a role for SV40 infection in human mesotheliomas and high risk of false-positive PCR results owing to presence of SV40 sequences in common laboratory plasmids. Lancet2004;364:1157–66
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    The potential causal role of simian virus 40 (SV40) in tumourigenesis is the most contentious issue in mesothelioma research of recent years. SV40 is a potent tumour virus and can induce mesothelioma in experimental animals. However, clinical evidence linking SV40 with mesothelioma remains inconclusive. SV40 has been reported in human mesothelioma tissues …

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