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A murine model of CF lung disease
  1. D McKeon
  1. CF Trust Research Fellow, Papworth Hospital, Cambridge, UK; mckeon@doctors.org.uk

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CFTR null mice do not develop spontaneous pulmonary disease and the mechanistic link between altered ion transport and the pathogenesis of CF has remained unclear. In this paper, Mall et al have generated transgenic mice that overexpress the ENaC epithelial Na+ channel and …

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