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Cytokine receptors and fibroblast proliferation in interstitial pneumonia
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  1. O C Ioachimescu
  1. Cleveland Clinic Foundation, Cleveland, USA; oioac@yahoo.com

https://doi.org/10.1136/thx.2004.la0110

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    ▴ Jakubzick C, Choi ES, Carpenter KJ, et al. Human pulmonary fibroblasts exhibit altered interleukin-4 and interleukin-13 receptor subunit expression in idiopathic interstitial pneumonia. Am J Pathol2004;164:1989–2001
    OpenUrlPubMedWeb of Science

    Fibroblasts play a pivotal role in the pathogenesis of idiopathic interstitial pneumonia (IIP). Interleukin (IL)-4 and IL-13 are Th2-type profibrotic cytokines that exert their effects on fibroblasts via multimeric receptors comprised of several shared subunits: IL-4Rα, IL-13Rα1, IL-13Rα2, and γ. This study examined the differential expression of IL-4 and IL-13 receptors …

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