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Cytokine receptors and fibroblast proliferation in interstitial pneumonia
  1. O C Ioachimescu
  1. Cleveland Clinic Foundation, Cleveland, USA; oioac@yahoo.com

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Fibroblasts play a pivotal role in the pathogenesis of idiopathic interstitial pneumonia (IIP). Interleukin (IL)-4 and IL-13 are Th2-type profibrotic cytokines that exert their effects on fibroblasts via multimeric receptors comprised of several shared subunits: IL-4Rα, IL-13Rα1, IL-13Rα2, and γ. This study examined the differential expression of IL-4 and IL-13 receptors …

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