Article Text

Acute effects of cigarette smoke on inflammation and oxidative stress: a review
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  1. H van der Vaart,
  2. D S Postma,
  3. W Timens,
  4. N H T Ten Hacken
  1. Department of Pulmonology and Pathology, University Hospital Groningen, Groningen, The Netherlands
  1. Correspondence to:
    H van der Vaart
    Department of Pulmonology, University Hospital Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands; H.van.der.vaartint.azg.nl

Abstract

Compared with the effects of chronic smoke exposure on lung function and airway inflammation, there are few data on the acute effects of smoking. A review of the literature identified 123 studies investigating the acute effects of cigarette smoking on inflammation and oxidative stress in human, animal, and in vitro models. An acute smoking model is a relatively easy and sensitive method of investigating the specific effects of cigarette smoke on oxidative stress and inflammation. Acute smoke exposure can result in tissue damage, as suggested by increased products of lipid peroxidation and degradation products of extracellular matrix proteins. Acute cigarette smoke has a suppressive effect on the number of eosinophils and several inflammatory cytokines, possibly due to the anti-inflammatory effect of carbon monoxide. An acute smoking model can supplement other ways of studying the effects of smoking and is an as yet underinvestigated method for intervention studies in smoking related diseases.

  • ACS, acute cigarette smoking
  • AMs, alveolar macrophages
  • BALF, bronchoalveolar lavage fluid
  • CO, carbon monoxide
  • COPD, chronic obstructive pulmonary disease
  • CS, cigarette smoke
  • CSE, cigarette smoke extract
  • EIC, elastase inhibitory capacity
  • GSH, reduced glutathione
  • GSSG, oxidised glutathione
  • HO-1, heme oxygenase-1
  • IFN-γ, interferon-γ
  • IL, interleukin
  • NE, neutrophil elastase
  • NO, nitric oxide
  • PMNs, polymorphonuclear cells
  • TBARS, thiobarbituric acid reactive substances
  • TEAC, trolox equivalent antioxidant capacity
  • TNF-α, tumour necrosis factor α
  • chronic obstructive pulmonary disease
  • smoking
  • inflammation
  • oxidative stress

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Supplementary materials

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    Files in this Data Supplement:

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      Table S1
      Twenty five studies examining the acute effects of cigarette smoking (ACS) in humans

      Table S2
      37 studies examining the acute effects of cigarette smoke in animal models

      Table S3
      Sixty two studies examining the acute effects of cigarette smoke in in vitro models

Footnotes

  • This review was supported by a grant from Astra Zeneca.

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