Background: Proinflammatory cytokines stimulate osteoclast activity and this could lead to increased bone resorption in patients with cystic fibrosis. The aim of this study was to determine whether markers of systemic inflammation are related to changes in bone mineral content (BMC) in adults with cystic fibrosis.
Methods: Total body BMC was assessed by dual energy x ray absorptiometry in 100 patients (54 male) of mean (SD) age 25.6 (7.1) years and forced expiratory volume in 1 second (FEV1) 61.8 (24.1)% predicted on recruitment to the study and 1 year later. Blood was also taken at these time points to measure markers of systemic inflammation.
Results: After 1 year BMC had reduced by 16.1 (62.1) g, p = 0.01; (0.6 (2.8)%). The change in BMC was related to mean levels of interleukin (IL)-6 (rs = −0.39, p<0.001) and C reactive protein (rs = −0.34, p = 0.002), intravenous antibiotic use (rs = −0.27, p = 0.006) and oral corticosteroid use (rs = −0.20, p = 0.045). Urinary markers of osteoclast activity were also related to IL-6 (rs = 0.27, p = 0.02). Multiple linear regression revealed that IL-6 (coefficient –2.2 (95% CI –3.4 to –1.0) per pg/ml, p = 0.001), colonisation with Burkholderia cepacia (coefficient –46.8 (95% CI –75.5 to –18.1), p = 0.002), and annual change in BMI (coefficient 15.4 (95% CI 3.6 to 27.2) per kg/m2, p = 0.011) were independently significant predictors of annual change in BMC.
Conclusions: These data suggest a pathophysiological mechanism by which chronic pulmonary infection results in bone loss in patients with cystic fibrosis.
- BMC, bone mineral content
- BMD, bone mineral density
- BMI, body mass index
- BSAP, bone specific alkaline phosphatase
- CRP, Creactive protein
- FEV1, forced expiratory volume in 1 second
- IL-6, interleukin 6
- cystic fibrosis
- bone mineral content
Statistics from Altmetric.com
This study was funded by the Cystic Fibrosis Trust.
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.