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Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a meta-analysis
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  • Published on:
    Authors' Response
    • Don D. Sin
    • Other Contributors:
      • Wen Qi Gan, S. F. Paul Man, A. Senthilselvan

    Dear Editor

    The authors wish to thank Fimognari and colleagues for highlighting the difficult issue of defining chronic obstructive pulmonary disease (COPD). In most circumstances, a spirometric cutoff is used to define COPD, but there is no uniform consensus on what that should be and different expert panels have promulgated different spirometric cutoff values [1-4]. COPD is a disease characterized by lung inflam...

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    Conflict of Interest:
    None declared.
  • Published on:
    COPD, restrictive syndrome and inflammation
    • Filippo Fimognari, medical doctor
    • Other Contributors:
      • Leo Moro, Raffale Antonelli Incalzi

    Dear Editor

    in a recent issue of the Journal, Gan WQ et al. published a systematic review and meta-analysis of 14 reports which confirmed the strong association between COPD and biological markers of systemic inflammation [1]. In 6 reports, COPD was diagnosed according to the presence of a FEV1/FVC ratio lower than 0.7. However, in the remaining 8 studies this measure was not available, and authors assumed as affecte...

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    Conflict of Interest:
    None declared.