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Hypermethylation of FHIT predicts poor prognosis in NSCLC
  1. K Pavithran
  1. Consultant, Department of Medical Oncology, Rajiv Gandhi Cancer Institute & Research Centre, New Delhi, India;

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DNA methylation of CpG sites in the promoter regions of tumour suppressor genes is a frequently acquired epigenetic event in the pathogenesis of many human cancers. The fragile histidine triad (FHIT) gene, located at chromosome 3p14.2, is a tumour suppressor gene. Methylation results in …

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