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Hypermethylation of FHIT predicts poor prognosis in NSCLC
  1. K Pavithran
  1. Consultant, Department of Medical Oncology, Rajiv Gandhi Cancer Institute & Research Centre, New Delhi, India; drkpavithran@hotmail.com

https://doi.org/10.1136/thx.2004.la0094

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    ▴ Maruyama R, Sugio K, Yoshino I, et al. Hypermethylation of FHIT as a prognostic marker in non-small cell lung carcinoma. Cancer2004;100:1472–7.
    OpenUrlCrossRefPubMed

    DNA methylation of CpG sites in the promoter regions of tumour suppressor genes is a frequently acquired epigenetic event in the pathogenesis of many human cancers. The fragile histidine triad (FHIT) gene, located at chromosome 3p14.2, is a tumour suppressor gene. Methylation results in …

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