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Systemic bioactivity of inhaled fluticasone is not affected by the presence of emphysema
  1. A Jain
  1. Vallabh Bhai Patel Chest Institute, Delhi, India; Aj1974@rediffmail.com

https://doi.org/10.1136/thx.2004.la0096

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    ▴ Lipworth BJ, Lee DKC. The presence of emphysema does not affect the systemic bioactivity of inhaled fluticasone in severe chronic obstructive pulmonary disease. Br J Clin Pharmacol2004;57:388–92.
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    Inhaled corticosteroids reduce exacerbation frequency in COPD but it is not known whether the presence of emphysema, with decreased alveolar volume, results in impaired bioactivity. The systemic effects of fluticasone 2000 μg daily were compared in patients with COPD who did and did not have emphysema (COPDE and …

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