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Review series
Sleep · 2: Pathophysiology of obstructive sleep apnoea/hypopnoea syndrome
  1. R B Fogel,
  2. A Malhotra,
  3. D P White
  1. Division of Sleep Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
  1. Correspondence to:
    Dr R B Fogel
    Division of Sleep Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA; rfogelpartners.org

Abstract

The pathogenesis of airway obstruction in patients with obstructive sleep apnoea/hypopnoea syndrome is reviewed. The primary defect is probably an anatomically small or collapsible pharyngeal airway, in combination with a sleep induced fall in upper airway muscle activity.

  • obstructive sleep apnoea

https://doi.org/10.1136/thorax.2003.015859

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