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Increase in urinary leukotriene LTE4 levels in acute asthma: correlation with airflow limitation
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  • Published on:
    In reply: Urinary leukotriene LTE4 levels in non-responders to antileukotriene therapy
    • Stuart A Green, Director, Clinical Research
    • Other Contributors:
      • Marie-Pierre Malice, Theodore F. Reiss

    Dear Editor

    We thank Dr Lee for his interest in our reports.[1,2] However, he appears to confuse the terms “treatment failure” and “non-responder”. “Treatment failure,” as defined in the original report for our study,[1] referred to a clinical outcome (a composite endpoint of hospitalization, need for excluded medication, or need for prolonged acute asthma treatment in the emergency setting). In contrast, “non-responders”...

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    Conflict of Interest:
    None declared.
  • Published on:
    Urinary leukotriene LTE4 levels in non-responders to antileukotriene therapy

    Dear Editor

    I read with interest the recent article by Green et al. [1] showing that in acute asthma, activation of leukotriene pathways correlated with the degree of airflow obstruction, and a reduction in leukotriene levels was associated with resolution of asthma exacerbation.

    However, no analysis was performed on patients categorised as being in the treatment failure group, which was reported to...

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    Conflict of Interest:
    None declared.