You are here

Article Text

Article menu

Download PDFPDF

Respiratory muscles
Respiratory muscle strength and the risk of incident cardiovascular events
Free
  1. J van der Palen1,2,
  2. T D Rea1,
  3. T A Manolio3,
  4. T Lumley4,
  5. A B Newman5,
  6. R P Tracy6,
  7. P L Enright7,
  8. B M Psaty1
  1. 1Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA
  2. 2Department of Epidemiology, Medisch Spectrum Twente, Enschede, The Netherlands
  3. 3Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, MD, USA
  4. 4Department of Biostatistics, University of Washington, Seattle, WA, USA
  5. 5Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
  6. 6Department of Pathology, University of Vermont, Colchester, VT, USA
  7. 7College of Public Health, University of Arizona, Tucson, AZ, USA
  1. Correspondence to:
    Dr J van der Palen
    Department of Epidemiology, Medisch Spectrum Twente, Enschede, The Netherlands; vdpaleneuronet.nl

Abstract

Background: Maximal inspiratory pressure (MIP) is a measure of inspiratory muscle strength. The prognostic importance of MIP for cardiovascular events among elderly community dwelling individuals is unknown. Diminished forced vital capacity (FVC) is a risk factor for cardiovascular events which remains largely unexplained.

Methods: MIP was measured at the baseline examination of the Cardiovascular Health Study. Participants had to be free of prevalent congestive heart failure (CHF), myocardial infarction (MI), and stroke.

Results: Subjects in the lowest quintile of MIP had a 1.5-fold increased risk of MI (HR 1.48, 95% CI 1.07 to 2.06) and cardiovascular disease (CVD) death (HR 1.54, 95% CI 1.09 to 2.15) after adjustment for non-pulmonary function covariates. There was a potential inverse relationship with stroke (HR 1.36, 95% CI 0.97 to 1.90), but there was little evidence of an association between MIP and CHF (HR 1.22, 95% CI 0.93 to 1.60). The addition of FVC to models attenuated the HR associated with MIP only modestly; similarly, addition of MIP attenuated the HR associated with FVC only modestly.

Conclusions: A reduced MIP is an independent risk factor for MI and CVD death, and a suggestion of an increased risk for stroke. This association with MIP appeared to be mediated through mechanisms other than inflammation.

  • CHF, congestive heart failure
  • CVD, cardiovascular disease
  • FEV1, forced expiratory volume in 1 second
  • FVC, forced vital capacity
  • MI, myocardial infarction
  • MIP, maximal inspiratory pressure
  • RV, residual volume
  • respiratory muscles
  • cardiovascular disease
  • congestive heart failure
  • stroke
  • maximal inspiratory pressure

https://doi.org/10.1136/thx.2004.021915

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    View Full Text

    Footnotes

    • Sources of support: National Heart, Lung, and Blood Institute

    Linked Articles

    • airwaves
      Airwaves
      Wisia Wedzicha
      Thorax 2004; 59 1005-1005 Published Online First: 24 Nov 2004. doi: 10.1136/thx.2004.awdec