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Adjunct prednisolone therapy does not improve survival in HIV-associated tuberculous pleurisy
  1. R Johns
  1. MRC Clinical Research Fellow, University College London, UK; r.johns@ucl.ac.uk

https://doi.org/10.1136/thx.2004.la0123

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    ▴ Elliott AM, Luzze H, Quigley MA, et al. A randomized, double-blind, placebo-controlled trial of the use of prednisolone as an adjunct to treatment in HIV-1-associated pleural tuberculosis. J Infect Dis2004;190:869–78
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    Glucocorticoids reduce excessive inflammation in pleural tuberculosis and have been shown to hasten resolution in HIV negative patients. Active tuberculosis can speed progression of HIV infection since HIV replicates more rapidly in activated lymphocytes. Given that prednisolone therapy is associated with reduced immune activation in HIV positive subjects, the …

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