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Low birth weight for gestation and airway function in infancy: exploring the fetal origins hypothesis
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  1. C Dezateux1,
  2. S Lum2,
  3. A-F Hoo2,
  4. J Hawdon3,
  5. K Costeloe4,
  6. J Stocks2
  1. 1Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, London, UK
  2. 2Portex Anaesthesia, Intensive Therapy and Respiratory Medicine Unit, Institute of Child Health and Great Ormond Street NHS Trust, London, UK
  3. 3University College London Hospital, London, UK
  4. 4Barts and the London, Queen Mary School of Medicine and Dentistry, Homerton University Hospital, London, UK
  1. Correspondence to:
    Professor C Dezateux
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK; c.dezateuxich.ucl.ac.uk

Abstract

Background: Poor fetal growth has been associated with impaired airway function in adult life, but evidence linking birth weight and airway function in early childhood is sparse. We examined the hypothesis that low birth weight for gestation is associated with impaired airway function shortly after birth and that this is independent of impaired postnatal somatic growth.

Methods: Airway function was measured using the raised volume technique in healthy white infants of low (⩽10th centile) or appropriate (⩾20th centile) birth weight for gestation and was expressed as forced expiratory volume in 0.4 s (FEV0.4), forced vital capacity (FVC), and the maximal expired flow at 25% of forced vital capacity (MEF25). Infant length and weight, maternal height and weight, maternal report of smoking prenatally and postnatally, and parental occupation were recorded.

Results: Mothers of low birth weight for gestation infants (n = 98) were lighter, shorter, and more likely to smoke and have partners in manual occupations. At 6 weeks their infants remained lighter and shorter than those of appropriate birth weight (n = 136). FEV0.4, FVC, and MEF25 were reduced in infants of low birth weight for gestation, in those whose mothers smoked in pregnancy, or who were in manual occupations. After adjusting for relevant maternal and infant characteristics, infants in the low birth weight for gestation group experienced a mean reduction of 11 ml in FEV0.4 (95% CI 4 to 18; p = 0.002), of 12 ml in FVC (95% CI 4 to 19; p = 0.004), and of 28 ml/s in MEF25 (95% CI 7 to 48; p = 0.03).

Conclusions: Airway function is diminished in early postnatal life as a consequence of a complex causal pathway which includes social disadvantage as indicated by maternal social class, smoking and height, birth weight as a proximal and related consequence of these factors, and genetic predisposition to asthma. Further work is needed to establish the relevance of these findings to subsequent airway growth and development in later infancy and early childhood.

  • birth weight
  • fetal growth retardation
  • fetal origins hypothesis
  • airway function
  • infants
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Footnotes

  • This work was carried out with grants from the Dunhill Medical Trust and the Foundation for the Study of Infant Death. A-FH and JS are supported by Portex plc. Research at the Institute of Child Health and Great Ormond Street Hospital for Children NHS Trust benefits from R&D funding received from the NHS Executive.

  • CD and JS conceived the study and, with KC, were responsible for the study design; JH and KC assisted with recruitment; SL and AFH recruited and measured infants and, together with JS, calculated airway function parameters; CD and SL were responsible for statistical analyses and drafted the manuscript. All authors contributed to interpretation and commented on the manuscript.

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