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Health outcomes following treatment for 6 months with once daily tiotropium compared with twice daily salmeterol in patients with COPD
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  • Published on:
    Authors' reply
    • Vito Brusasco, Professor of Respiratory Medicine
    • Other Contributors:
      • Richard Hodder, Marc Miravitlles, L arry Korducki, Leslie Towse, and Steven Kesten

    Dear Editor

    In his letter, Dr Devoy is questioning the strength of the conclusion in our publication regarding the clinical efficacy of salmeterol on dyspnea, quality of life and reductions of exacerbations. We had stated that the effects with long-acting ß2-adrenergic bronchodilators on COPD exacerbations and on other health outcomes has provided inconsistent results [1] We note that Dr Devoy’s argument is mo...

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    Conflict of Interest:
    None declared.
  • Published on:
    Reflecting the balance of evidence for salmeterol in COPD
    • Michael B Devoy, Vice President Respiratory, Clinical Development and Medical Affairs Europe

    Dear Editor

    We would like to comment on strength of conclusions of the recent publication by Dr Brusasco et al,[1] particularly that no consideration is given to how the results compare to the balance of evidence that exists.

    The paper’s conclusions imply superior efficacy of tiotropium over salmeterol in patients with COPD by emphasising endpoints in which tiotropium shows a difference compar...

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    Conflict of Interest:
    None declared.