Relationship of anti-GM-CSF antibody concentration, surfactant protein A and B levels, and serum LDH to pulmonary parameters and response to GM-CSF therapy in patients with idiopathic alveolar proteinosis

J F Seymour; I R Doyle; K Nakata; J J Presneill; O D Schoch; E Hamano; K Uchida; R Fisher; A R Dunn

doi:10.1136/thorax.58.3.252

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Relationship of anti-GM-CSF antibody concentration, surfactant protein A and B levels, and serum LDH to pulmonary parameters and response to GM-CSF therapy in patients with idiopathic alveolar proteinosis

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	Abstract	Full	Pdf
Feb 2003	1	4	1
Mar 2003	53	128	49
Apr 2003	7	68	38
May 2003	12	56	24
Jun 2003	4	31	27
Jul 2003	24	76	9
Aug 2003	17	37	19
Sep 2003	22	42	16
Oct 2003	23	71	15
Nov 2003	22	37	14
Dec 2003	23	28	4
Jan 2004	29	46	9
Feb 2004	21	39	11
Mar 2004	28	51	39
Apr 2004	27	43	19
May 2004	48	59	19
Jun 2004	40	75	30
Jul 2004	32	59	10
Aug 2004	37	86	19
Sep 2004	41	78	12
Oct 2004	20	71	31
Nov 2004	8	91	19
Dec 2004	7	83	18
Jan 2005	23	57	17
Feb 2005	15	82	15
Mar 2005	24	43	20
Apr 2005	6	28	19
May 2005	11	27	17
Jun 2005	10	62	22
Jul 2005	7	26	6
Aug 2005	10	36	15
Sep 2005	8	31	15
Oct 2005	6	34	28
Nov 2005	6	32	22
Dec 2005	8	20	16
Jan 2006	10	27	8
Feb 2006	1	19	6
Mar 2006	7	37	11
Apr 2006	12	13	12
May 2006	3	33	14
Jun 2006	3	9	6
Jul 2006	1	14	12
Aug 2006	8	15	10
Sep 2006	10	13	12
Oct 2006	6	12	7
Nov 2006	3	24	7
Dec 2006	6	27	16
Jan 2007	6	12	7
Feb 2007	8	26	17
Mar 2007	4	35	13
Apr 2007	17	8	7
May 2007	18	10	6
Jun 2007	7	9	5
Jul 2007	7	19	10
Aug 2007	16	7	8
Sep 2007	15	9	4
Oct 2007	10	6	11
Nov 2007	11	5	5
Dec 2007	6	6	4
Jan 2008	18	4	6
Feb 2008	15	12	10
Mar 2008	30	7	6
Apr 2008	15	9	4
May 2008	9	5	5
Jun 2008	14	4	6
Jul 2008	19	6	4
Aug 2008	56	4	1
Sep 2008	26	12	4
Oct 2008	21	18	10
Nov 2008	9	4	6
Dec 2008	8	6	6
Jan 2009	18	3	5
Feb 2009	16	2	5
Mar 2009	23	2	2
Apr 2009	20	3	3
May 2009	12	4	1
Jun 2009	21	7	6
Jul 2009	22	3	1
Aug 2009	11	7	5
Sep 2009	22	2	5
Oct 2009	27	5	5
Nov 2009	39	7	4
Dec 2009	10	0	1
Jan 2010	16	2	5
Feb 2010	23	3	5
Mar 2010	16	4	5
Apr 2010	21	8	6
May 2010	16	3	2
Jun 2010	13	7	5
Jul 2010	11	10	6
Aug 2010	18	10	3
Sep 2010	11	6	3
Oct 2010	25	3	2
Nov 2010	16	6	2
Dec 2010	14	7	2
Jan 2011	18	3	2
Feb 2011	8	5	2
Mar 2011	13	2	5
Apr 2011	17	3	4
May 2011	18	1	2
Jun 2011	8	0	0
Jul 2011	11	4	4
Aug 2011	12	6	4
Sep 2011	16	6	2
Oct 2011	21	8	3
Nov 2011	19	9	7
Dec 2011	10	20	18
Jan 2012	13	15	4
Feb 2012	17	14	7
Mar 2012	12	14	8
Apr 2012	19	21	15
May 2012	24	13	14
Jun 2012	10	19	6
Jul 2012	11	30	9
Aug 2012	13	12	10
Sep 2012	12	15	13
Oct 2012	21	13	15
Nov 2012	15	14	17
Dec 2012	11	13	15
Jan 2013	19	13	9
Feb 2013	16	2	10
Mar 2013	13	13	12
Apr 2013	12	6	11
May 2013	34	6	9
Jun 2013	29	17	8
Jul 2013	20	9	6
Aug 2013	19	8	6
Sep 2013	9	9	5
Oct 2013	11	6	3
Nov 2013	16	53	2
Dec 2013	19	58	5
Jan 2014	14	20	5
Feb 2014	16	15	7
Mar 2014	11	14	2
Apr 2014	17	12	3
May 2014	18	14	12
Jun 2014	13	8	6
Jul 2014	30	13	14
Aug 2014	26	10	5
Sep 2014	6	7	4
Oct 2014	10	9	2
Nov 2014	8	20	7
Dec 2014	11	9	3
Jan 2015	11	18	5
Feb 2015	6	8	4
Mar 2015	18	13	7
Apr 2015	11	3	1
May 2015	6	1	1
Jun 2015	14	10	8
Jul 2015	7	5	10
Aug 2015	10	5	2
Sep 2015	15	14	2
Oct 2015	5	1	1
Nov 2015	4	0	14
Dec 2015	15	4	2
Jan 2016	17	9	9
Feb 2016	12	10	1
Mar 2016	15	7	9
Apr 2016	8	3	6
May 2016	6	6	4
Jun 2016	13	3	2
Jul 2016	14	1	4
Aug 2016	12	5	3
Sep 2016	19	4	9
Oct 2016	33	4	9
Nov 2016	30	13	14
Dec 2016	18	3	5
Jan 2017	26	4	4
Feb 2017	6	1	2
Mar 2017	10	26	15
Apr 2017	7	19	0
May 2017	3	11	4
Jun 2017	12	24	3
Jul 2017	15	13	2
Aug 2017	33	27	1
Sep 2017	32	18	4
Oct 2017	41	29	2
Nov 2017	39	29	5
Dec 2017	11	7	4
Jan 2018	27	9	3
Feb 2018	29	21	9
Mar 2018	22	22	2
Apr 2018	24	16	2
May 2018	18	14	1
Jun 2018	24	16	7
Jul 2018	18	12	9
Aug 2018	7	5	1
Sep 2018	17	7	3
Oct 2018	19	19	7
Nov 2018	23	19	8
Dec 2018	16	10	3
Jan 2019	10	8	4
Feb 2019	24	18	2
Mar 2019	15	11	10
Apr 2019	18	10	8
May 2019	15	13	2
Jun 2019	9	9	11
Jul 2019	9	8	11
Aug 2019	16	14	4
Sep 2019	19	13	8
Oct 2019	16	14	11
Nov 2019	14	9	8
Dec 2019	22	14	5
Jan 2020	17	15	6
Feb 2020	12	6	3
Mar 2020	13	9	7
Apr 2020	13	9	7
May 2020	26	19	6
Jun 2020	30	26	9
Jul 2020	11	10	1
Aug 2020	22	18	10
Sep 2020	37	29	8
Oct 2020	56	44	10
Nov 2020	22	17	12
Dec 2020	17	17	10
Jan 2021	22	16	6
Feb 2021	15	13	10
Mar 2021	31	27	5
Apr 2021	20	12	10
May 2021	9	7	5
Jun 2021	13	13	11
Jul 2021	12	12	6
Aug 2021	7	7	8
Sep 2021	14	14	9
Oct 2021	28	22	20
Nov 2021	8	2	15
Dec 2021	17	16	6
Jan 2022	17	14	6
Feb 2022	19	21	6
Mar 2022	19	23	11
Apr 2022	29	25	2
May 2022	41	35	11
Jun 2022	45	39	7
Jul 2022	18	20	5
Aug 2022	47	39	5
Sep 2022	37	35	7
Oct 2022	60	56	8
Nov 2022	22	21	9
Dec 2022	23	19	5
Jan 2023	35	36	16
Feb 2023	31	29	0
Mar 2023	26	20	8
Apr 2023	12	6	3
May 2023	21	15	11
Jun 2023	9	9	3
Jul 2023	14	13	8
Aug 2023	36	32	4
Sep 2023	32	21	4
Oct 2023	15	11	2
Nov 2023	21	19	11
Dec 2023	42	38	10
Jan 2024	47	33	9
Feb 2024	34	32	10
Mar 2024	22	21	31
Total	4533	4779	2110

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