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Leukotriene receptors are overexpressed in aspirin sensitive asthmatics
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Patients with aspirin sensitivity, asthma, and nasal polyps exhibit increased synthesis of cysteinyl leukotrienes—both basally and in response to exogenous aspirin—and increased responsiveness to inhaled cysteinyl leukotrienes, in contrast to patients with aspirin tolerant asthma. The authors hypothesised that the latter effect …