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Spotting latent infection: the path to better tuberculosis control
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  • Published on:
    Author's reply
    • Ajit Lalvani, Wellcome Senior Clinical Research Fellow & Honorary Consultant Physician

    Dear Editor

    I thank Mishra and colleagues for their cogent comments about the potential clinical utility of ELISPOT for diagnosis of tuberculosis infection in high burden countries, such as India.[1]

    The high prevalence of latent tuberculosis infection in Indian adults [2] means that ELISPOT (as with any test of tuberculosis infection, as opposed to active disease) cannot be used to routinely ‘rule in’ a...

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    Conflict of Interest:
    None declared.
  • Published on:
    Use of ELISPOT for latent tuberculosis: utility in countries with a high burden of infection.
    • Pravas Pratap Mishra, Senior Resident in Haematology
    • Other Contributors:
      • Chaterjee T,Dixit A,Kumar Rajat, Saxena R, Mahapatra M,Choudhry VP

    Dear Editor

    We read with interest your article for detection of latent tuberculosis.[1]

    As the author has pointed out, this test is perhaps more useful for those countries with a low burden of infection. However, even then, it is surprising that there is only one study on Indian subjects.[2] Using this test, the authors recorded a 80% prevalence for latent tuberculosis in healthy adult Indians, compared t...

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    Conflict of Interest:
    None declared.