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Management of COPD
  1. T K Marras1
  1. 1Toronto General Hospital, Toronto, Ontario M5G 2C4, Canada;

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In their recent review1 MacNee and Calverley provided an excellent summary of the management of COPD. However, I question their assertions regarding domiciliary oxygen. Citing the work of Gorecka et al2 and Chaouat et al,3 it is stated that domiciliary oxygen does not benefit patients with relatively mild hypoxaemia or isolated nocturnal desaturation.

Gorecka et al studied 135 patients with oxygen tension 7.4–8.7 kPa (56–65 mm Hg) randomised to domiciliary oxygen versus control.2 As previously noted, this study was underpowered to detect potential significant mortality benefits. …

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