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BRADYKININ SUPPRESSES ALLERGEN INDUCED NO
Patients with atopic asthma have increased levels of exhaled nitric oxide (FENO), reflecting inducible nitric oxide synthase (iNOS) expression. In contrast, bradykinin activates constitutive NOS. In this issue of Thorax Ricciardolo and colleagues describe the mechanism of this effect of bradykinin inhalation after allergen challenge, before and after pretreatment with an NOS inhibitor. They show for the first time that bradykinin inhalation suppresses allergen induced FENO during the late phase in atopic asthma, while the NOS inhibitor does not potentiate this effect. This suggests that bradykinin could switch off the increased NO production during an exacerbation and thus an acute inflammatory mediator may actually be used to reduce the severity of an asthma exacerbation. What an interesting novel therapeutic target!
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NON-INVASIVE VENTILATION AND FREQUENT EXACERBATORS
Some patients with COPD are prone to frequent exacerbations, …
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