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Urokinase in the treatment of childhood empyema
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  1. S C Sit1,
  2. G Cohen1,
  3. A Jaffe1
  1. 1Departments of Respiratory Medicine and Cardiothoracic Surgery, Great Ormond Street Hospital for Children, London SW3 6NP, UK
  1. Correspondence to:
    Dr A Jaffe, Consultant and Honorary Senior Lecturer in Respiratory Research, Great Ormond Street Hospital for Children, Great Ormond Street, London SW3 6NP, UK;
    a.jaffe{at}ich.ucl.ac.uk

https://doi.org/10.1136/thorax.58.1.93-a

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    Thomson et al reported the first double blind placebo controlled study of intrapleural urokinase for the treatment of childhood empyema.1 They found a statistically significant reduction in hospital stay in the treatment group and concluded that “urokinase is a successful adjunct to the management of parapneumonic empyema”.

    The primary management of childhood empyema is controversial with some groups advocating open decortication.2 However, because of reports of wound infection, air leaks and bleeding in open decortication, there has been an increase in the potential for video assisted thorascopic surgery (VATS) as primary treatment for childhood empyema.3 We have recently reported our experience in 21 …

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