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Comparison of atopic cough with cough variant asthma: is atopic cough a precursor of asthma?
  1. M Fujimura1,
  2. H Ogawa2,
  3. Y Nishizawa2,
  4. K Nishi3
  1. 1Third Department of Internal Medicine, Kanazawa University School of Medicine, Kanazawa, Japan
  2. 2Division of Internal Medicine, Ishikawa-ken Saiseikai Kanazawa Hospital, Kanazawa, Japan
  3. 3Division of Pulmonary Medicine, Ishikawa Prefectural Central Hospital, Kanazawa, Japan
  1. Correspondence to:
    Dr M Fujimura, Third Department of Internal Medicine, Kanazawa University School of Medicine, Kanazawa 920–8641, Japan;
    fujimura{at}med3.m.kanazawa-u.ac.jp

Abstract

Background: We have described a group of patients who present with isolated chronic bronchodilator resistant non-productive cough with an atopic constitution, eosinophilic tracheobronchitis, and airway cough receptor hypersensitivity without bronchial hyperresponsiveness, which we have termed “atopic cough”. Although cough variant asthma (in which the cough responds to bronchodilators) is recognised as a precursor of typical asthma, it is not known whether atopic cough is also a precursor of asthma.

Methods: Eighty two patients with atopic cough were retrospectively examined for onset of typical asthma and compared with 55 patients with cough variant asthma (20 untreated patients and 35 treated with long term inhaled beclomethasone dipropionate (BDP), 218–467 μg/day). The median follow up period for patients with atopic cough and cough variant asthma was 4.8 (1–11.5) years and 3.7 (1–12.4) years, respectively.

Results: Onset of typical asthma occurred in only one of the patients with atopic cough. In patients with cough variant asthma, typical asthma developed in two of 35 patients taking BDP and six of 20 untreated patients (difference 24.3%, 95% CI 2.8 to 45.8, p<0.02).

Conclusions: These findings suggest that cough variant asthma is a precursor of typical asthma but that atopic cough is not. Treatment with inhaled steroids may prevent the transformation of cough variant asthma into typical asthma.

  • atopic cough
  • cough variant asthma
  • asthma
  • outcome

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