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I was interested in the article by Burns and Gibson in the February issue of Thorax,1 but feel that the authors should exclude the following possible confounding factors which should be addressed before their hypothesis can be accepted.
The time course of the bronchoconstrictor response to deep breaths in mild asthma is brief (usually 60–90 seconds), so the precise timing of the sGaw measurements after the manoeuvre is critical. Have the authors taken this into consideration?
Although the pre-test and test breathing pattern was standardised …
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