Article Text
Review series
Chronic obstructive pulmonary disease • 1: Susceptibility factors for COPD the genotype–environment interaction
Abstract
Genetic factors including α1-antitrypsin deficiency are important in COPD. Candidate gene association studies in COPD are reviewed. Efforts to identify interactions between genetic factors and environmental determinants such as smoking may lead to improved understanding of the pathogenesis of the disease.
- chronic obstructive pulmonary disease
- genotype-environment interaction
- genetics
- smoking