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Molecular epidemiology of tuberculosis in London 1995–7 showing low rate of active transmission
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  • Published on:
    Re: Sampling in tuberculosis RFLP clustering analyses
    • Helen Maguire, Consultant Regional Epidemiologist
    • Other Contributors:
      • Timothy D McHugh; On behalf of the Steering Committee; Molecular Epidemiology of Tuberculosis in London

    Dear Editor

    Paynter and Coker have made an important point about the extent to which clustering depends upon sample coverage. We believe that this is valid, but strictly correct only in the situation where a representative (e.g. random) sample of the population have been studied. In our study we included 2490 isolates with linked demographic information. This is 77 % of the total of 3260 culture-confirmed cases...

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    Conflict of Interest:
    None declared.
  • Published on:
    Sampling in tuberculosis RFLP clustering analyses

    Dear Editor

    Maguire et al.[1] estimated recently in the journal that the rate of recent transmission of M tuberculosis in London was 14.4 % between 1995 and 1997. Estimation of this parameter is an important contribution to the understanding of transmission dynamics of tuberculosis in the capital and should assist policy-makers in developing responses to enhance control. We suggest, however, that if this estim...

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    Conflict of Interest:
    None declared.