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Relationship between asthma severity and progression of Alzheimer's disease
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  1. T Ohrui,
  2. H Arai,
  3. M Ichinose,
  4. T Matsui,
  5. M Yamaya,
  6. H Sasaki
  1. Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, Sendai 980-8574, Japan
  1. Correspondence to:
    Dr H Sasaki, Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan;
    dept{at}geriat.med.tohoku.ac.jp

https://doi.org/10.1136/thorax.57.6.561

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    Severity of asthma is occasionally modulated by neuropsychiatric conditions.1 However, little is known about the impact of cognitive decline on asthma severity. Cognitive decline is a core symptom in patients with Alzheimer's disease (AD).2 AD is a disease characterised by progressive cholinergic failure3 that could possibly reduce airway hyperresponsiveness to cholinergic stimulation and thus symptoms of asthma. Furthermore, the functions of T lymphocytes—which play a crucial role in the development of chronic asthma—are partially impaired in patients with AD related diseases.4 We hypothesised that declining cognitive function might result in an improvement in asthma, and prospectively studied the contribution of the progression of …

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